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Let's Prevent - Study Information 

Let's Prevent Diabetes

Let's Prevent - Preventative Education for those with Pre-Diabetes

A Randomised Controlled Study for the Prevention of Diabetes using an Educational Intervention and Continuous Support Programme in those with Pre-Diabetes in a Multi Ethnic Population.

Let's Prevent is funded by a National Institute for Health Research (NIHR) Programme Grant and is the first randomised controlled study looking at whether an educational lifestyle programme (of diet and exercise) can prevent those with a condition called pre-diabetes going on to develop diabetes. 

Diabetes and impaired glucose tolerance (IGT) are increasingly appearing in younger people and, before the onset of diabetes, most people will have some degree of abnormal glucose tolerance, as has been found in previous screening studies such as STAR & ADDITION. The most efficient way to address the problem of diabetes and its complications is to prevent diabetes from developing. 

Research on patients with impaired glucose tolerance has shown that prevention is possible, particularly using lifestyle modification interventions.


Aims of the study


The aim of the study is to establish whether the use of a structured lifestyle modification programme (based on the DESMOND curriculum) prevents those with pre-diabetes going on to develop diabetes.

Recruitment to Let' Prevent is only via GP practices and it is not possible for participants to volunteer directly for this study. 


The main aims of the study are to provide:


  • A multi-disciplinary approach to reducing the progression to diabetes in high risk people
  • An appropriate structured education programme to target lifestyle modification and behaviour change and a culturally sensitive structured education for the Black Minority and Ethnic (BME) community
  • A support and motivational maintenance programme for the duration of the study


And to:  


  • Evaluate the programme to provide a low cost solution for practical health improvement



A screening programme has been run on 44 different GP practice databases to identify those 40-75 of European origin or aged 25-75 of South Asian origin or those who have previous Impaired Fasting Glucose (IFG) or Impaired Glucose Tolerance (IGT).

A risk score was then applied (with weightings for gender, ethnicity, family history of diabetes and hypertension). The top 10% of those identified received a letter from their GP inviting them to attend a screening session to see if they have pre-diabetes. Recruitment for this study is now closed.

Thanks to everyone who took at interest in the study, we have recruited our target of 748 people!

People in the study are still attending clinic sessions and will continue to do so through 2013 and into 2014, with the last participant scheduled for their final visit in July 2014. We hope to publish our first results in about 18 months time, although some of the early findings have already been presented at scientific conferences in the UK and in Europe - details listed below.


  • Gray L.J, Khunti K, William S, Goldby S, Troughton J, Yates T, Gray A, Davies MJ (2012) Let's Prevent Diabetes: study protocol for a cluster randomised controlled trial of an educational intervention in a multi-ethnic UK population with screen detected impaired glucose regulation. Cardiovascular Diabetology, 11:56
  • S Williams, LJ Gray, K Khunti, S Goldby, T Yates, MJ Davies (2011) Baseline data of the Let's Prevent diabetes screening study. Poster Presentation - Diabetes UK 2011
  • S Goldby, LJ Gray, K Khunti, S Williams, D Sheppard, N Taub, T Yates, MJ Davies (2011) Using the Leicester practice risk score to identify people with diabetes and impaired glucose regulation. Poster Presentation - Diabetes UK 2011

Accepted by Diabetologia for publication:


  • LJ Gray, K Khunti, C Edwardson, S Goldby, J Henson, DH Morris, D Sheppard, D Webb, S Williams, T Yates, MJ Davies (2012) Implementation of the automated Leicester Practice Risk Score in two diabetes prevention trials provides a high yield of people with abnormal glucose tolerance


For further information 


Please contact the project lead Stephanie Goldby.

T: 0116 258 7249


Copyright © The DESMOND Collaborative 2008. All rights reserved.